“Genomic approaches to epigenetic inheritance,” 3/27

Wednesday, March 27, 2013 at 12:00pm to 1:00pm

HMS New Research Building, Room 350 77 Avenue Louis Pasteur

“Genomic approaches to epigenetic inheritance,” 3/27
Dr. Oliver Rando
University of Massachusetts Medical School 

Our lab studies epigenetic inheritance in yeast and mouse. In yeast, we focus on the dynamics of histone proteins during the process of genomic replication. Curiously, we find that ancestral histone proteins accumulate at the 5’ends of genes, raising the question of what role this histone accumulation plays in gene regulation. In mice, we study the role of paternal environment in influencing the phenotype of offspring. Specifically, we find that offspring of males fed a low-protein diet exhibited elevated hepatic expression of many genes involved in lipid and cholesterol biosynthesis and decreased levels of cholesterol esters, relative to the offspring of males fed a control diet. These results, in conjunction with recent human epidemiological data, indicate that parental diet can affect cholesterol and lipid metabolism in offspring and define a model system to study environmental reprogramming of the heritable epigenome. I will also discuss ongoing efforts to understand the mechanistic basis for this phenomenon, using in vitro fertilization and epigenomic mapping in sperm.

Date & Time:  3/27/2013 12:00pm  -  1:00pm
Location: HMS New Research Building, Room 350

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Basic Science, Population Science

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Amelia Careghini

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CCSB_Admin@dfci.harvard.edu

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